芮梦龙

发布者：王玲发布时间：2022-02-21浏览次数：10549

芮梦龙,副研究员,博士研究生导师

E-mail: ruimenglong@seu.edu.cn

办公室:西汉姆联江北校区汇川楼A408

个人简介

2017年于西汉姆联获得博士学位，2018-2020于Temasek Life Sciences Laboratory从事博士后研究，2021年加入bw必威西汉姆联。主持国家自然科学基金，江苏省自然科学基金，南京市留学人员科技创新项目择优资助，西汉姆联“至善青年学者”A层次项目；作为骨干入选首批“西汉姆联学科交叉青年特支计划”；参与科技部重大、国自然重点基金多项；兼任江苏省神经科学学会理事；Journal of Translational Medicine, Neural Regeneration Research, GeroScience, Current Neuropharmacology‌, Developmental Neuroscience, Int J Mol Sci, Scientific Reports, Biology等期刊Reviewer。


研究方向

发育相关的突触修剪通过消除冗余或不当的神经连接来重塑神经回路，从而优化信息处理、关键期可塑性及兴奋抑制平衡。越来越多的证据表明，在敏感发育期突触修剪的失调是神经发育障碍（尤其是自闭症谱系障碍, ASD）的共同病理机制。我们的研究旨在利用果蝇，小鼠以及脑类器官模型阐明调控发育性突触修剪的细胞与分子机制，并揭示这些过程失调如何导致ASD的病理生理学机制。

先前研究成果总结如下图所示：


发表论文(# co-first author; * corresponding author;Descending by Year)：

  1. Wanting Wang#, Su Wang#, Yuhao Yuan,Menglong Rui*. Ribbon Constrains Dendritic Pruning via Actin Scaffolding and Exocyst Complex.Cellular & Molecular Biology Letters. 2026 Apr 2.

  2. Shuliu Zhang#, Sifan Gong#, Yiming Yang, Wenting Gong, Qingxia Zhou, Kun Yang,Menglong Rui*, Su Wang*. Casein kinase 2 maintains the self-renewal of neural stem cells via prospero phosphorylation inDrosophila.Cell & Bioscience. 2026 Jan 28;16(1):23.

  3. Sifan Gong#, Shuliu Zhang#, Xu Yan, Wenting Gong, Qingxia Zhou, Xiaojing Yang, Kun Yang*,Menglong Rui*, Su Wang*. N-myristoyl Transferase Maintains Type II Neuroblasts through Notch Signaling inDrosophila.Neuroscience Bulletin. 2026 Jan 3.

  4. Keyao Long#, Erqian Huang#, Yuhao Yuan, Su Wang*,Menglong Rui*. Steering Axon Development: Glial Cell Mechanisms inDrosophila.ACS Chemical Neuroscience. 2025 Sep 17;16(18):3438-3449.

  5. Ting Zheng, Keyao Long, Su Wang,Menglong Rui*. Glial-derived TNF/Eiger signaling promotes somatosensory neurite sculpting.Cellular and Molecular Life Sciences. 2025 Jan 21;82(1):47.

  6. Bin Wang #, Limin Xu#,Menglong Rui*. Progress in Drug-targeted Therapy for Papillary Thyroid Carcinoma.Current Oncology Reports. 2025 Nov;27(11):1331-1345.

  7. Keyao Long, Wanyue Xu, Xun Miao, Su Wang*,Menglong Rui*. Live Cell Imaging to Monitor Axonal Pruning inDrosophila Motor Neurons.Bio-protocol. 2025 Jul 5;15(13): e5367.

  8. Qingxia Zhou#, Fuhao Zhang#, Sifan Gong, Shuliu Zhang, Wenting Gong,Menglong Rui*, Su Wang*. Split Ends Inhibits the Dedifferentiation of imINP to Prevent the Generation of Supernumerary Type II Neuroblasts inDrosophila.Cells. 2025 Dec 4;14(23):1926.

  9. Wanting Wang,Menglong Rui*. Advances in understanding the roles of actin scaffolding and membrane trafficking in dendrite development.Journal of Genetics and Genomics. 2024 Nov;51(11):1151-1161.

  10. Menglong Rui*. Recent progress in dendritic pruning ofDrosophila C4da sensory neurons.Open Biology. 2024 Jul;14(7):240059.

  11. Ziyang Gao, Erqian Huang, Wanting Wang, Lizhong Xu, Wanyue Xu, Ting Zheng,Menglong Rui*. Patronin regulates presynaptic microtubule organization and neuromuscular junction development inDrosophila.iScience. 2024 Jan 18;27(2):108944.

  12. Menglong Rui*, Weiyu Kong, Wanting Wang, Ting Zheng, Su Wang*, Wei Xie. Droj2 Facilitates Somatosensory Neurite Sculpting via GTP-Binding Protein Arf102F inDrosophila.Int J Mol Sci. 2023 Aug 25;24(17):13213.

  13. Wanyue Xu, Weiyu Kong, Ziyang Gao, Erqian Huang, Wei Xie, Su Wang*,Menglong Rui*. Establishment of a novel axon pruning model ofDrosophilamotor neuron.Biology Open. 2023 Jan 1;12(1): bio059535.

  14. Menglong Rui#, Kay Siong Ng#, Quan Tang, Shufeng Bu, Fengwei Yu*. Protein phosphatase PP2A regulates microtubule orientation and dendrite pruning inDrosophila.EMBO Reports. 2020 Mar 6;21 (5): e48843.

  15. Menglong Rui#, Shufeng Bu#, Liang Yuh Chew#, Qiwei Wang, Fengwei Yu*. The membrane protein Raw regulates dendrite pruning via the secretory pathway.Development. 2020 Oct 9;147(19): dev191155.

  16. Yan Wang#,Menglong Rui#, Quan Tang, Shufeng Bu, Fengwei Yu*. Patronin governs minus-end-out orientation of dendritic microtubules to promote dendrite pruning inDrosophila.Elife. 2019 Mar 28;8: e39964.

  17. Menglong Rui, Jinjun Qian, Lijuan Liu, Huihui Lv, Junhai Han, Zhengping Jia and Wei Xie*. The neuronal protein Neurexin directly interacts with the Scribble-Pix complex to stimulate F-actin assembly for synaptic vesicle clustering.Journal of Biological Chemistry. 2017 Sep 1;292(35): 14334-14348.

  18. QuanTang,Menglong Rui, Shufeng Bu, Yan Wang, Liang Yuh Chew, and Fengwei Yu*. A microtubule polymerase is required for microtubule orientation and dendrite pruning inDrosophila.The EMBO Journal. 2020 May 18;39(10): e103549.

  19. Huanhuan Zhang,Menglong Rui, Zhixin Ma, Sifan Gong, Shuliu Zhang, Qingxia Zhou, Congfeng Gan, Wenting Gong, Su Wang*. Golgi-to-ER retrograde transport prevents premature differentiation ofDrosophila type II neuroblasts via Notch-signal-sending daughter cells.iScience. 2023 Nov 22;27(1):108545.

  20. Xinwang Zhang,Menglong Rui, Guangmin Gan, Cong Huang, Jukang Yi, Huihui Lv, Wei Xie*. Neuroligin4 regulates synaptic growth via the bone morphogenetic protein (BMP) signaling pathway at theDrosophila neuromuscular junction.Journal of Biological Chemistry. 2017 Nov 3;292(44):17991-18005.

  21. Renjun Tu, Jinjun Qian,Menglong Rui, Nana Tao, Mingkuan Sun, Yan Zhuang, HuihuiLv, Junhai Han, Moyi Li and Wei Xie*. Proteolytic cleavage is required for functional neuroligin 2 maturation and trafficking inDrosophila.Journal of Molecular Cell Biology. 2017 Jun 1;9(3): 231-242.

  22. Zhixin Ma, Wenshu Wang, Xiaojing Yang,Menglong Rui, Su Wang*. Glial ferritin maintains neural stem cells via transporting iron required for self-renewal inDrosophila.Elife. 2024 Sep 10;13:RP93604.

  23. Guanglin Xing#, Moyi Li#, Yichen Sun,Menglong Rui, Yan Zhuang, Huihui Lv, Junhai Han, Zhengping Jia*, Wei Xie*. Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex inDrosophila neuromuscular junction.Elife. 2018 Mar 14;7: e30457.

  24. Yichen Sun, Moyi Li*, Junhua Geng, Sibie Meng, Renjun Tu, Yan Zhuang, Mingkuan Sun,Menglong Rui, Mengzhu Ou, Guangling Xing, Travis K Johnson, Wei Xie*. Neuroligin 2governs synaptic morphology and function through RACK1-cofilin signaling inDrosophila.Communications Biology. 2023 Oct 18;6(1):1056.

  25. Yu Zhao, Junhua Geng, Zhu Meng, Yichen Sun, Mengzhu Ou, Lizhong Xu, Moyi Li, Guangming Gan,Menglong Rui, Junhai Han, Wei Xie. Neurexin facilitates glycosylation of Dystroglycan to sustain muscle architecture and function inDrosophila. Communications Biology. 2024 Nov 9;7(1):1481.

  26. Xi Xiao, Changyan Chen, Tian-ming Yu, Jiayao Ou,Menglong Rui, Yuanfen Zhai,Yijing He, Lei Xue, and Margaret S. Ho*. Molecular Chaperone Calnexin Regulatesthe Function ofDrosophila Sodium Channel Paralytic.Frontiers in Molecular Neuroscience. 2017 Mar 7;10:57.

  27. Jianzheng He, Alice Mei Xien Tan, SiYun Ng,Menglong Rui, Fengwei Yu*. Cannabinoids modulate food preference and consumption inDrosophila melanogaster.Scientific Reports. 2021 Feb 25;11(1):4709.