高山，西汉姆联，首席教授，博导。
办公地点：西汉姆联科技产业园（栖霞区）高等研究院
个人简介：
英国牛津大学医学肿瘤学博士，先后在牛津和剑桥大学从事科研工作。主要研究方向聚焦在肿瘤驱动突变及其表观调控和免疫逃逸机制研究。以通讯作者在Mol Cell (2026) 、Journal Clinical Investigation (2026) 、Proc Natl Acad Sci U S A（2025,2023,2022,2020）、Nature Communications(2025,2024)、Science Bulletin (2025,2024)、Journal Experimental Medicine (2024)、Cancer Research（2025,2021,2019）等杂志发表40多篇论文。公开专利23项（包括三个国际PCT），获得授权10个（包括国际PCT专利二项）。
研究方向：
Ø肿瘤驱动突变、表观调控和分子机理；
Ø药物机理和生物标志物
Ø肿瘤免疫治疗技术和分子机理
代表文章（均为最后/唯一通讯作者）
1.Jiang S Y, Sun J H, Gao Y, Zhang H F, He Y, Zhang Y B, Xu Z Y, Cheng S W, Yan H, Duan L Q, Xu P, Ye Q L, Gao S*. ICAM1 mRNA entraps ILF2/ILF3 to inhibit transcription of EIF4E and global protein synthesis. Molecular Cell.86(2):332-344.e8. doi: 10.1016/j.molcel (2026).
2.Gu Y M, Pan Y B, Pan C, Pang Q, Tang Z T, Chen Y W, Zang H J, Wang X D, Huang C, Zhang Q Q, Yang F C, Zhu X F, Zhang Y B, Zhao X J, Gao S*.Post-transcriptional regulation of PD-1 by PRMT5/WDR77 complex shapes T cell effector function and anti-tumor immunity.Journal of Clinical Investigation. 136(3): e191469. doi: 10.1172/JCI191469 (2026).
3.Zhang Y B, Wang X D, Gu Y M, Liu T F, Zhao X J, Cheng S W, Duang L Q, Huang C, Wu S Z, Gao S*. Complement C3 of tumor-derived extracellular vesicles promotes metastasis of RCC via recruitment of immunosuppressive myeloid cells. Proceedings of the National Academy of Sciences of the United States of America, 122(4):e2420005122. doi: 10.1073/pnas.2420005122 (2025).
4.Pan Y B, Gu Y M, Liu T H, Zhang Q Q, Yang F C, Duan L Q, Cheng S W, Zhu X F, Xi Y B, Chang X L, Ye Q N, Gao S*. Epitranscriptic regulation of HRAS by N6-methyladenosine drives tumor progression. Proceedings of the National Academy of Sciences of the United States of America, 120(14):e2302291120. doi:10.1073/pnas.2302291120 (2023).
5.Yang X W, Wen Y, Liu S M, Duan L Q, Liu T F, Tong Z, Wang Z, Gu Y M, Xi Y B, Wang X D, Luo D S, Zhang R B, Liu Y J, Wang Y, Cheng T Y, Jiang S Y, Zhu X F, Yang X H, Pan Y B, Cheng S W, Ye Q N, Chen J F*, Xu X D*, Gao S*. LCDR regulates the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival. Proceedings of the National Academy of Sciences of the United States of America, 119(5):e2110428119, doi:10.1073/pnas.2110428119 (2022).
6.Wang X D, Yang X H, Zhang C, Wang Y, Cheng T Y, Duan L Q, Tong Z, Tan S G, Zhang H J, Saw P E, Gu Y M, Wang J H, Zhang Y B, Shang L N, Liu Y J, Jiang S Y, Yan B X, Li R, Yang Y, Yu J, Chen Y Z, Gao G F*, Ye Q N, Gao S*. Tumor cell-intrinsic PD-1 receptor is a tumor suppressor and mediates resistance to PD-1 blockade therapy. Proceedings of the National Academy of Sciences of the United States of America, 117, 6640-6650, doi:10.1073/pnas.1921445117 (2020).
7.Wang X T, Liu T F, Li Y F, Ding A, Zhang C, Gu Y M, Zhao X J, Cheng S W, Duan L Q, Cheng T Y, Wu S Z, Duan L Q, Zhang J H, Yin R, Shang M, Gao S*. A splicing isoform of PD-1 promotes tumor progression as a potential immune checkpoint. Nature Communications, 15(1):9114. doi: 10.1038/s41467-024-53561-2 (2024).
8.Yang X H, Ding A, Wu S Z, Jiang Z Y, Li Y F, Huang X T, Duan L Q, Cheng S W, Zheng S Z, Gao S*. FuHsi regulates rDNA transcription and promotes tumor progression. Science Bulletin (Beijing), S2095-9273(25)00494-3. doi: 10.1016/j.scib.2025.04.068 (2025).
9.Jiang S Y, Han X Q, Liu T H, He Y, Zhao Z D, Liu T F, Cheng S W, Zhang J H, Duan L Q, Liu Y J, Cheng T Y, Liu Y, Ye Q N, Gao S*. HUNK inhibits cargo uptake and lysosomal traffic in the caveolar pathway via the AGAP3/ARF6. Science Bulletin (Beijing), 69(2):173-178. doi: 10.1016/j.scib.2023.11.053 (2024).
10.Huang C, Wang X D, Gu Y M, Ren K, Zang H J, Zhang Y B, Pan Y B, Cheng S W, Zhu X F, Wu S Z, Duan L Q, Xu X J, Ye Q L, Zeng J, Hu H B, Gao, S*. METTL14 Enhances Antitumor Immunity through m6A-Dependent Loss of PD-1. Cancer Research. 85:4151-4163, doi: 10.1158/0008-5472 (2025).
11.Gu Y M, Niu S X, Wang Y, Duan L Q, Pan Y B, Tong Z, Zhang X, Yang Z Y, Peng B, Wang X D, Han X Q, Li Y X, Cheng T Y, Liu Y J, Shang L N, Liu T F, Yang X W, Sun M X, Jiang S Y, Zhang C, Zhang N, Ye Q N, Gao S*.DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A Reader IGF2BP3 Drives ccRCC Progression. Cancer Research, 81, 923-934, doi:10.1158/0008-5472.Can-20-1619 (2021).
12.Jiang S Y, Wang X T, Song D L, Liu X J, Gu Y M, Xu Z Y, Wang X D, Zhang X L., Ye Q N, Tong Z, Yan B X, Yu J, Chen Y Z, Sun M X, Wang Y, Gao S*. Cholesterol Induces Epithelial-to-Mesenchymal Transition of Prostate Cancer Cells by Suppressing Degradation of EGFR through APMAP. Cancer Research, 79, 3063-3075, doi:10.1158/0008-5472.Can-18-3295 (2019).
13.Zang H J, Liu T F, Wang X D, Cheng S W, Zhu X F, Huang C, Duan L Q, Zhao X J, Guo F, Wang X T, Zhang C, Yang F C, Gu Y M*, Hu H B*, Gao S*. PD-1IR2 promotes tumor evasion via deregulating CD8+ T cell function. Journal for ImmunoTherapy of Cancer, 13(3):e010529. doi: 10.1136/jitc-2024-010529 (2025).
14.Wen Y, Yang X W, Li Y F, Zhao X Q, Ding A, Song D L, Duan L Q, Cheng S W, Zhu X F, Peng B, Chang X L, Zhang C, Yang F C, Cheng T Y, Wang H, Zhang Y B, Zhang T T, Zheng S Z, Ren L*, Gao S*. DRAIC mediates hnRNPA2B1 stability and m6A-modified IGF1R instability to inhibit tumor progression. Oncogene, 43(29):2266-2278. doi: 10.1038/s41388-024-03071-8 (2024).
15.Wang X D, Yang X H, Huang C, Liu T F, Zang H J, Gu Y M, Zhang Y B, Zhu X F, Zhang C, Guo F, Wu S Z, Ding A, Yin R, Ye Q N, Gao S*. Tumor-derived extracellular vesicle PD-1 promotes tumor immune evasion via disruption of peripheral T cell homeostasis. Cancer Letters, 612:217486. doi: 10.1016/j.canlet.2025.217486 (2025).
16.Peng B, Cheng S W, Wang H, Liu T F, Gu Y M, Duan L Q, Cheng T Y, Wang X T, Wang X D, Zhang Q Q, Zhang Y B, Zhao X Q, Yao X J, Zhao X J, Song D L*, Zeng J*, Gao S*.N6-methyladenosine enhances the expression of TGF-β-SMAD signaling family to inhibit cell growth and promote cell metastasis. Cancer Letters, 603:217195. doi: 10.1016/j.canlet.2024.217195 (2024).
17.Liu T F, Cheng S W, Peng B, Zang H J, Zhu X F, Wang X T, Zhao X J, Gu Y M, Pan Y B, Hu H B*, Gao S*. PD-L2 of tumor-derived exosomes mediates the immune escape of cancer cells via the impaired T cell function. Cell Death & Disease, 15(11):800. doi: 10.1038/s41419-024-07191-7 (2024).
18.Han X Q, Jiang S Y, Gu Y M, Ding L H, Zhao E H, Cao D X, Wang X D, Wen Y, Pan Y B, Yan X, Duan L Q, Sun M X, Zhou T, Liu Y J, Hu H B*, Ye Q N*, GaoS*. HUNK inhibits epithelial-mesenchymal transition of CRC via direct phosphorylation of GEF-H1 and activating RhoA/LIMK-1/CFL-1. Cell Death & Disease, 14(5):327, doi:10.1038/s41419-023-05849-2 (2023).
19.Zhu Y M, Liu X J, Wang Y, Pan Y B, Han X Q, Peng B, Zhang X, Niu S X, Wang H, Ye Q N, Gu Y M*, Gao, S*.DMDRMR promotes angiogenesis via antagonizing DAB2IP in clear cell renal cell carcinoma. Cell Death & Disease, 13(5):456. doi:10.1038/s41419-022-04898-3 (2022).
