Jian Li, Professor, PhD
Vice Chairman of Bioinformatics Society of Jiangsu Province
Email: jianli2014@seu.edu.cn
Research fields: Bioinformatics; Artificial Intelligence applications; Space life sciences
Research Experience
My research focuses on bioinformatics and artificial intelligence applications. Prior to joining Southeast University in 2014, I was visiting scientist, principal investigator and post-doctoral fellow in Department of Biomedicine, Aarhus University (Denmark) from 2008 to 2014. He received his bachelor degree of medicine from School of Clinical Medicine, Southeast University in 2001 and PhD at Human Genetics Institute, University of Aarhus in 2008.
Research Projects
Data on biological systems is being generated at an unprecedented speed by new omics techniques and AI. Consequently, we are rapidly accumulating information about all aspects of life. In AI Era, bioinformatics and systems biology are rapidly extending their applications in comprehensive biomedical research fields. My research interest is to develop and apply bioinformatics tools to advance our understanding of life and genome. Major projects are as follows:
● Development of novel algorithms to understand life complex and dynamics
● Investigating the mechanism of adaptation of human in spaceflight
● Deepening understand of the human genome, its modification and evolution
Selected Publications
1. Linhuan Chen, Yangyang Hao, Tianzhang Zhai, Fan Yang, Shuqiu Chen, Xue Lin and Jian Li, (corresponding author), Single-cell analysis highlights anti-apoptotic subpopulation promoting malignant progression in bladder cancer, Cancer Informatics, 2025, 24: 1-16.
2. Jianhua Rao, Chao Song, Yangyang Hao, Zaozao Chen, Sidu Feng, Shihui Xu, Xiaoyue Wu, Zhengfeng Xuan, Ye Fan, Wenzhu Li, Junda Li, Yong Ren, Jian Li (corresponding author), Feng Cheng; Zhongze Gu, Leveraging Patient-Derived Organoids for Personalized Liver Cancer Treatment, International Journal of Biological Sciences, 2024, 20(13): 5363-5374.
3. Chongxin Tao, Yun Bai, Jiang Chen, Jing Lu, Yan Bi, Jian Li (corresponding author), Detection of Glutamate Decarboxylase Antibodies and Simultaneous Multi-Molecular Translocation Exploration by Glass Nanopores, Biosensor, 2024, 14, 255.
4. Jian Li, Weicheng Liang, Xingyu Li, Pan Gu, Anna Liu, Pin Chen, Qiwei Li, Xueyin Mei, Jing Yang, Jun Liu, Lincao Jiang, Zaozao Chen, Zhongze Gu, OOCDB: A Comprehensive, Systematic, and Real-time Organs-on-a-chip Database, Genomics, Proteomics & Bioinformatics (2023), doi: doi.org/10.1016/j.gpb.2023.01.001.
5. Zepeng Sun, Xinlong Liu, Wei Liu, Jiahui Li, Jing Yang, Feng Qiao, Jianjun Ma, Jingjie Sha, Jian Li, (corresponding author), Li-Qun Xu, AutoNanopre: An Automated Adaptive and Robust Method to Locate Translocation Events in Solid-State Nanopore Current Traces, ACS Omega, 2022.
6. Yangyang Hao, Liang Lu, Anna Liu, Xue Lin, Li Xiao, Xiaoyue Kong, Kai Li, Fengji Liang, Jianghui Xiong, Lina Qu, Yinghui Li, Jian Li (corresponding author), Integrating bioinformatic strategies in spatial life science research, Briefings in Bioinformatics, 2022.
7. Xingyu Li, Lin Xue, Xueyin Mei, Pin Chen, Anna Liu, Weicheng Liang, Shan Chang, Jian Li (corresponding author), HLA3D-an integrated structure-based computational toolkit for immunotherapy, Briefings in Bioinformatics, 2022.
8. Xue Lin, Yingyinghua, Shuanglin Gu, Li Lv, Xingyu Li, Pin Chen, Peng Dai, Yunyun Hu, Anna Liu, Jian Li (corresponding author), kataegis: an R package for identification and visualization of the genomic localized hypermuation regions using high-throughput sequencing, BMC Genomics, 2021.